Common inherited genetic variants that together increase the risk of breast cancer by about a fifth have been identified by scientists.

A huge team of researchers working together around the world uncovered 65 new variants. On their own, they contribute around 4% of the two-fold heightened risk of women with a strong family history of breast cancer developing the disease.

Adding these variants to the list of 180 already known is thought to account for an estimated 18% of the relative familial risk.

Test for breast cancer risk could reduce pre-emptive mastectomies

In addition, a further 10 genetic variants specifically linked to stubborn breast cancers that do not respond to hormone treatment were found. They could be responsible for as much as 16% of the increased risk of this cancer sub-type in women from affected families.

The OncoArray Consortium project involved 550 researchers from around 300 different institutions on six continents. The scientists analysed genetic data from 275,000 women, including 146,000 who had been diagnosed with breast cancer.

Professor Doug Easton, one of the lead investigators from Cambridge University, said: “These findings add significantly to our understanding of the inherited basis of breast cancer.

“As well as identifying new genetic variants, we have also confirmed many that we had previously suspected.

“There are some clear patterns in the genetic variants that should help us understand why some women are predisposed to breast cancer, and which genes and mechanisms are involved.”

Genetic studies of this sort look for “loci” – regions of DNA that increase the risk of disease. The loci may contain rogue genes, or DNA sequences that do not contain instructions for making proteins but regulate gene activity.

Pinpointing specific genes is difficult, but the OncoArray scientists were able to make predictions about many target genes – a first step towards designing new treatments.

However most of the new variants found were in gene-regulating regions. When the researchers took a closer look at these, they found distinct patterns specific to breast cancer.

US co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease.

“This should provide guidance for a lot of future research,” he added.

Approximately 70% of all breast cancers are fuelled by the hormone oestrogen and respond to hormone therapies such as tamoxifen.

Others, known as oestrogen-receptor negative, are not affected by the hormone and are more difficult to treat. Ten new genetic variants linked to these cancers were identified.

Women with BRCA gene mutations given clearer picture of breast and ovarian cancer risk

The new studies, published in the journals Nature and Nature Genetics, underscored the fact that the two cancer types are biologically distinct and develop differently.

Mutant versions of the two genes BRCA1 and BRCA2 have by far the biggest impact on breast cancer risk. Inheriting either of these genes raises the lifetime risk of developing the disease by as much as 90% for BRCA1 and 85% for BRCA2. It also increases the risk of ovarian cancer to a lesser degree.

Other genetic variants linked to breast cancer are much less potent on their own, but their effects add up. Those identified in the new studies are relatively common – some carried by one woman in 100 and others by more than half of all women. The combined effect of these variants is likely to be considerable said the researchers.

They estimate that 1% of women have a risk of breast cancer more than three times greater than that of women in the general population. Combining the genetic factors with hormonal and lifestyle influences was likely to increase the risk further, they said.

Professor Jacques Simard, from Laval University in Quebec city, Canada, another member of the international team, said: “Using data from genomic studies, combined with information on other known risk factors, will allow better breast cancer risk assessment, therefore helping to identify a small but meaningful proportion of women at high risk of breast cancer.

“These women may benefit from more intensive screening, starting at a younger age, or using more sensitive screening techniques, allowing early detection and prevention of the disease.”

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