Are you talking about scientifically trying to prove that something is tangible? Sure, within the realm of scientific experiments, as in observational science, of course you are going to go through a process in an attempt to verify, to confirm the evidence regarding alleged claim of the reality of something.
Yes. Very good. Yes.
Let's go with "evolution".
Well, a long time ago, it was simply a hypothesis.
Then, as people discovered more evidence and found the hypothesis useful for making predictions, it was upgraded to a theory (a useful hypothesis).
And now that we've been able to observe and document the process of "speciation" it's now an empirically verifiable fact.
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RE: MAGNUM MYSTERIUM